Definition of OPERATE

to control the mechanical operation of <do not operate heavy machinery, including cars, after taking this medication>
Synonyms handle, run, work
to look after and make decisions about <it takes years to learn how to operate that kind of business so that it makes money>
to produce a desired effect <the medicine will take an hour or so to operate the first time you use it>
Synonyms operate, perform, take, work
Near Antonyms backfire; fizzle
to put into action or service <wouldn't dream of operating a vehicle under the influence of alcohol>
Near Antonyms ignore, neglect; misapply, misuse

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