excruciation

a state of great suffering of body or mind <had never experienced such excruciation as when he contracted shingles> Synonyms affliction, agony, anguish, distress, hurt, misery, pain, rack, strait(s), torment, torture, travail, tribulation, woeRelated Words discomfort; cross, crucible, trial; heartache, heartbreak, joylessness, sadness, sorrow, unhappiness; emergency, pinch; asperity, difficulty, hardship, rigor; ache, pang, smarting, soreness, stitch, throe, twinge; danger, jeopardy, troubleNear Antonyms comfort, consolation, solace; alleviation, assuagement, ease, relief; peace, security; well-being