as in contaminated
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1
as in polluted
to make unfit for use by the addition of something harmful or undesirable
supplies of meat that had been defiled by maggots
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2
as in violated
to treat (a sacred place or object) shamefully or with great disrespect
art conservators were careful not to do anything that might defile the holy relic
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Merriam-Webster unabridged
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