cytokine

noun

cy·​to·​kine ˈsī-tə-ˌkīn How to pronounce cytokine (audio)
plural cytokines
: any of a class of immunoregulatory proteins (such as interleukin or interferon) that are secreted by cells especially of the immune system
Most cytokines are produced primarily in the presence of disease or immunization and contribute to immune responses, inflammation, and endothelial cell activation; others are involved in tissue repair.Charles A. Dinarello et al.
The proinflammatory cytokine interleukin-2 determines the magnitude and duration of the T-cell response immediately after antigen encounter and assists in the maturation of macrophages and the proliferation of B cells and natural killer cells …Chiea C. Khor et al.

Examples of cytokine in a Sentence

Recent Examples on the Web
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Different genes for different cytokines, growth factors or other proteins could be swapped in to target specific diseases of the ocular surface, potentially extending the approach beyond corneal wounds to chronic inflammatory conditions. Samantha Agate, Charlotte Observer, 16 June 2026 One of the body’s natural defense mechanisms against a virus like COVID or influenza is the release of cytokines, proteins that act as chemical messengers helping to coordinate the immune system’s response. Los Angeles Times, 15 June 2026 The body naturally relies on small chemical messengers called cytokines to control inflammation and healing. Khloe Quill, FOXNews.com, 5 June 2026 The virus appears to trigger a destructive host response in which infected endothelium, immune activation, platelets, coagulation, cytokine signaling, and complement converge to destabilize the vascular barrier. Steve Brozak, Forbes.com, 15 May 2026 See All Example Sentences for cytokine

Word History

Etymology

cyt- + -kine (as in lymphokine)

First Known Use

1974, in the meaning defined above

Time Traveler
The first known use of cytokine was in 1974

Cite this Entry

“Cytokine.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/cytokine. Accessed 4 Jul. 2026.

Medical Definition

cytokine

noun
cy·​to·​kine ˈsīt-ə-ˌkīn How to pronounce cytokine (audio)
: any of a class of immunoregulatory proteins (as interleukin, tumor necrosis factor, and interferon) that are secreted by cells especially of the immune system

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