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Medical Dictionary

von Willebrand factor

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noun von Wil·le·brand factor \vän-ˈvil-ə-ˌbränt-\

Medical Definition of von Willebrand factor

  1. :  a large glycoprotein clotting factor circulating in blood plasma that mediates platelet adhesion to collagen at sites of vascular injury, that binds to and protects factor VIII from degradation, and that is deficient or defective in individuals affected with von Willebrand disease <Patients are deficient in the von Willebrand factor, one of the many blood-clotting proteins.—Paul G. Donohue, The Springfield (Massachusetts) Union-News, 6 July 1994> Von Willebrand factor is synthesized in endothelial cells of blood vessels and in megakaryocytes of bone marrow. —called also VW factor



Biographical Note for von willebrand factor

Willebrand, Erik Adolf von (1870–1949), Finnish physician. He described von Willebrand's disease first in 1926 and again in 1931 in a follow-up article.


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