tumor suppressor gene
Medical Definition of tumor suppressor gene
: any of a class of genes (as p53 and APC) that act in normal cells to inhibit unrestrained cell division and that when inactivated (as by mutation) place the cell at increased risk for malignant proliferation <In some cases [of cancer], growth-inhibiting genes called tumor suppressor genes are damaged, allowing cells to proliferate unchecked.—Faye Flam, The Philadelphia Inquirer, 29 Sept. 2010> <In most human-cancer cells, there are multiple mutations—some that activate oncogenes and some that silence tumor-suppressor genes.—Robert A. Weinberg and Anthony L. Komaroff, Newsweek, 23 June 2008>—called also anti-oncogene
Variants of tumor suppressor gene
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