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sarsaparilla1 a: any of various tropical American plants of the genus Smilax b: any of various plants (as wild sarsaparilla, Aralia nudicaulis) that resemble or are used as a substitute for the sarsaparillas2 a: the dried roots of any of several sarsaparillas of the genus Smilax (especially S. aristolochiaefolia, S. febrifuga, and S. regelii) used now especially as a flavoring and formerly for the diaphoretic, expectorant, and laxative effects of the saponins found in them and without curative effect in the treatment of syphilis b: the roots of wild sarsaparilla (Aralia nudicaulis) used similarly
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