psychoactive

adjective

psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv How to pronounce psychoactive (audio)
: affecting the mind or behavior
psychoactive drugs

Examples of psychoactive in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Two of these are tetrahydrocannabinol, or THC, the compound known for causing feelings of euphoria and relaxation, and CBD, which has no psychoactive effect. Tribune News Service, Baltimore Sun, 19 Feb. 2026 The compound, which is found in a variety of plants and animals, is the psychoactive ingredient in the drug ayahuasca, the above source stated. Khloe Quill, FOXNews.com, 19 Feb. 2026 Since hemp is non-intoxicating the state must address recreational marijuana policy, which is used for psychoactive effects. Eleanor Dearman, Fort Worth Star-Telegram, 14 Feb. 2026 Two of these are tetrahydrocannabinol, or THC, the compound known for causing feelings of euphoria and relaxation, and CBD, which has no psychoactive effect. Miriam Fauzia, Dallas Morning News, 4 Feb. 2026 See All Example Sentences for psychoactive

Word History

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of psychoactive was in 1958

Browse Nearby Words

Cite this Entry

“Psychoactive.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/psychoactive. Accessed 26 Feb. 2026.

Kids Definition

psychoactive

adjective
psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv How to pronounce psychoactive (audio)
: affecting the mind or behavior
psychoactive drugs

Medical Definition

psychoactive

adjective
psy·​cho·​ac·​tive ˌsī-kō-ˈak-tiv How to pronounce psychoactive (audio)
: affecting the mind or behavior
psychoactive drugs
THC is the principal psychoactive ingredient in marijuana
Last Updated: - Updated example sentences
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