Medical Definition of phosphodiester bond
: a covalent bond in RNA or DNA that holds a polynucleotide chain together by joining a phosphate group at position 5 in the pentose sugar of one nucleotide to the hydroxyl group at position 3 in the pentose sugar of the next nucleotide—called also
Seen and Heard
What made you want to look up phosphodiester bond? Please tell us where you read or heard it (including the quote, if possible).