phenotype

1 of 2

noun

plural phenotypes
1
: the observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment : the physical expression of one or more genes
Considering that modern maize is a tetraploid, it is remarkable how many single gene mutations cause profound changes in phenotype.Virginia Walbot
A breed is a group of genetically related individuals with a common phenotype—physical characteristics, such as ear and muzzle shapes, and behavioral tendencies, such as those of a retriever to swim or a border collie to herd …Mark Derr
Phenotype is how that DNA physically manifests itself—in this case, as the susceptibility to disease, or the progression of disease, or the susceptibility of the disease itself to treatment, all of which likely have a genetic component.Gary Taubes
2
: the observable characteristics or traits of a disease
… a mild disorder whose clinical phenotype overlaps with that of the Marfan syndrome …Petros Tsipouras et al.
phenotypic adjective
phenotypic variation
phenotypic expression
phenotypically adverb
phenotypically similar populations

phenotype

2 of 2

verb

phenotyped; phenotyping; phenotypes

transitive verb

: to determine, analyze, or predict all or part of a phenotype of
Red cells were phenotyped as M + or M -.Raymond L. Comenzo et al.
… a team … recently decided to examine the data collected so far to determine how many of the phenotyped mice had eye problems.Michelle Wong
The asthma in these patients was not phenotyped. We do not have any information regarding the eosinophil count or other markers such as exhaled oral nitric oxide in these subjects.Faria Nasim

Examples of phenotype in a Sentence

Recent Examples on the Web
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Noun
How can a species contain multiple distinct phenotypes — or sets of traits — without separating into two species? Marlowe Starling, Quanta Magazine, 21 May 2026 But not all of those differences are relevant to the phenotype—or appearance—of the bluebuck that the Colossal team wants to recreate. Jeffrey Kluger, Time, 30 Apr. 2026
Verb
The organizations seeing the greatest returns are leveraging platforms that connect genotype to phenotype to real-world outcomes, linking biological signal to clinical context to economic value. Lisa Gurry, Forbes.com, 29 June 2026 To Tobias Warnecke, a molecular evolutionary biologist at Imperial College London, fitness landscapes are an invaluable way to connect genotype to phenotype. Quanta Magazine, 11 Jan. 2022 See All Example Sentences for phenotype

Word History

Etymology

Noun

German Phänotypus, from Greek phainein to show + typos type

First Known Use

Noun

1910, in the meaning defined at sense 1

Verb

1959, in the meaning defined above

Time Traveler
The first known use of phenotype was in 1910

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Cite this Entry

“Phenotype.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/phenotype. Accessed 7 Jul. 2026.

Kids Definition

phenotype

noun
: the visible characteristics of a plant or animal that result from the combined effects of the genes and the environment

Medical Definition

phenotype

noun
1
: the observable characteristics or traits of an organism that are produced by the interaction of the genotype and the environment : the physical expression of one or more genes
Considerable data on ABO blood group phenotypes and alleles now exist showing marked differentiation between geographical areas such as Europe and Asia …J.A. Beardmore et al.
The mice also developed an osteoporotic phenotype that was not due to a defect in osteoblast differentiation, but rather to a marked decline in the output of bone matrix per osteoblast.Patrick Ducy et al.
2
: the observable characteristics or traits of a disease
… a mild disorder whose clinical phenotype overlaps with that of the Marfan syndrome …Petros Tsipouras et al.

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