osteogenesis imperfecta

noun

osteogenesis im·​per·​fec·​ta -ˌim-(ˌ)pər-ˈfek-tə 

: a hereditary disease caused by defective or deficient collagen production and marked by extreme brittleness of the long bones and a bluish color of the whites of the eyes

called also brittle bone disease, brittle bones

Examples of osteogenesis imperfecta in a Sentence

Recent Examples on the Web

The married couple, who were both born with osteogenesis imperfecta type 3, also known as brittle bone disease, have moved into their first apartment, are settling into newlywed life and beginning to explore the possibility of welcoming a baby together. — Kayla Grant, PEOPLE, 23 June 2026

That can be declared of Christopher Lynch, an awarding-winning Irish filmmaker based in London, who was born with osteogenesis imperfecta. — Shirl Leigh march 02, New Atlas, 2 Mar. 2026

Watson was born with osteogenesis imperfecta, or brittle bone disease, a genetic condition in which the body does not make enough collagen to keep bones strong. — Theresa Braine, Mercury News, 29 Dec. 2025

The actress was born with osteogenesis imperfecta, also known as brittle bone disorder, a genetic illness and collagen condition that leads to weak bones and related complications like short stature, bone deformities and fractures. — Taijuan Moorman, USA Today, 29 Dec. 2025

Word History

Etymology

New Latin, imperfect osteogenesis

First Known Use

1899, in the meaning defined above

Rhymes for osteogenesis imperfecta

• analecta
• ejecta
• insecta
• recta

Medical Definition

osteogenesis imperfecta

noun

osteogenesis im·​per·​fec·​ta -ˌim-pər-ˈfek-tə 

: a hereditary disease caused by defective or deficient collagen production and marked by extreme brittleness of the long bones and a bluish color of the whites of the eyes

called also brittle bone disease, brittle bones, fragilitas ossium, osteopsathyrosis