Medical Definition of motif
: a distinctive usually recurrent molecular sequence (as of amino acids or base pairs) or structural elements (as of secondary protein structures) <These RNA molecules have an intriguing structural motif, absent in normal RNA, that recognizes an amino acid and chemically binds to it, forming a novel type of RNA enzyme, or ribozyme.—Jessa Netting, Science News, 7 Apr. 2001> <Only about half these genes have recognizable motifs, or DNA-sequence patterns, that suggest possible functions.—Alan E. Guttmacher and Francis S. Collins, The New England Journal of Medicine, 7 Nov. 2002>
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