Medical Definition of monoclonal gammopathy
: any of various disorders marked by proliferation of a single clone of antibody-producing lymphoid cells resulting in an abnormal increase of a monoclonal antibody in the blood serum and urine and that include both benign or asymptomatic conditions and neoplastic conditions (as multiple myeloma and Waldenström's macroglobulinemia)—called also plasma cell dyscrasia; see m protein 2
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