Medical Definition of Laurence–Moon syndrome
: a genetic disorder that is a ciliopathy characterized especially by obesity, ataxia, learning disabilities, kidney abnormalities, short stature, subnormal development of the genital organs, retinitis pigmentosa, and type 2 diabetes ◆Laurence-Moon syndrome is inherited as an autosomal recessive trait requiring that both parents pass on a copy of the defective gene on a chromosome other than a sex chromosome. Laurence-Moon syndrome was first called Laurence-Moon-Biedl syndrome until cases presenting with polydactyly and without obesity led to creation of a new disease entity, Bardet-Biedl syndrome. Because the differences between Laurence-Moon syndrome and Bardet-Biedl syndrome are not always clearly defined, some consider Laurence-Moon syndrome to be a variant form of Bardet-Biedl syndrome.
Biographical Note for laurence–moon syndrome
John Zachariah (1830–1874), British physician, and
Robert Charles (1844–1914), American ophthalmologist. Laurence and Moon were the coauthors of the first description of the Laurence-Moon syndrome. Their 1866 description was based on four cases of retinitis pigmentosa occurring in the same family.
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