Medical Dictionary

Krebs cycle

noun \ˈkrebz-\

Medical Definition of KREBS CYCLE

:  a sequence of reactions in the living organism in which oxidation of acetic acid or acetyl equivalent provides energy for storage in phosphate bonds (as in ATP)—called also citric acid cycle, tricarboxylic acid cycle

Biographical Note for KREBS CYCLE

Krebs, Sir Hans Adolf (1900–1981), German-British biochemist. Krebs made major contributions to the understanding of metabolic processes. In 1932 he discovered with the German biochemist Kurt Henseleit a series of chemical reactions occurring in mammalian tissue by which ammonia is converted to urea. In 1937 he discovered an essential series of intermediate reactions in the oxidation of foodstuffs: the citric acid cycle. Now known as the Krebs cycle, these reactions have proved to be of vital importance in our understanding of metabolic processes in the cell. In 1953 he was awarded the Nobel Prize for Physiology or Medicine for his researches in metabolic processes.


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