hyaluronidase

noun

hy·​al·​uron·​i·​dase ˌhī(-ə)l-yu̇-ˈrä-nə-ˌdās 

-ˌdāz

: a mucolytic enzyme that facilitates the spread of fluids through tissues by lowering the viscosity of hyaluronic acid

Examples of hyaluronidase in a Sentence

Recent Examples on the Web

In these cases, dissolving the filler with hyaluronidase removes that puffiness entirely, without the need for surgery. —Kara Nesvig, Allure, 4 Aug. 2025

After allowing time for your lips to settle — typically a couple of weeks — a medical professional can reevaluate the symmetry, contour, and firmness of your lips and use hyaluronidase to dissolve some or all of the filler in a certain spot. —Carlos Wolf, Miami Herald, 11 July 2025

The hyaluronidase is then directly injected into the site of the hyaluronic acid dermal filler, and then the area is massaged. —Jackie Fields, People.com, 15 Jan. 2025

Giving them a better idea of where to insert the hyaluronidase. —Celeste Polanco, Essence, 13 Sep. 2024

How does Topilase compare to injectable hyaluronidase? —Jolene Edgar, Harper's BAZAAR, 23 Dec. 2022

Word History

Etymology

International Scientific Vocabulary, from hyaluronic (acid) + -idase (as in glucosidase)

First Known Use

1940, in the meaning defined above

Rhymes for hyaluronidase

• aminopeptidase
• anticholinesterase
• carboxypeptidase
• ablaze
• airways
• allays
• always
• amaze
• anglaise
• appraise
• archways
• arrays

Medical Definition

hyaluronidase

noun

hy·​al·​uron·​i·​dase -ˈrän-ə-ˌdās, -ˌdāz 

: a mucolytic enzyme that splits and lowers the viscosity of hyaluronic acid facilitating the spreading of fluid through tissues either advantageously (as in the absorption of drugs) or disadvantageously (as in the dissemination of infection), that occurs in many normal tissues, in malignant growths, in invasive bacteria, and in certain venoms, and that is used especially to aid in the dispersion of fluids (as local anesthetics) injected subcutaneously for therapeutic purposes

called also spreading factor