Medical Definition of hyaluronidase
: a mucolytic enzyme that splits and lowers the viscosity of hyaluronic acid facilitating the spreading of fluid through tissues either advantageously (as in the absorption of drugs) or disadvantageously (as in the dissemination of infection), that occurs in many normal tissues, in malignant growths, in invasive bacteria, and in certain venoms, and that is used especially to aid in the dispersion of fluids (as local anesthetics) injected subcutaneously for therapeutic purposes—called also spreading factor
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