Medical Definition of hot spot
1: a patch of painful moist inflamed skin on a domestic animal and especially a dog that starts as a response to a skin irritant (as an allergen or an insect or tick bite), that is rapidly worsened by scratching, chewing, or licking the affected area, and that may become seriously infected if not promptly cleaned and medicated
2: a site in genetic material (as DNA or a chromosome) having a high frequency of mutation or recombination
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