Medical Definition of histoplasmosis
plural histoplasmoses \-ˌsēz\play
: a respiratory disease with symptoms like those of influenza that is endemic in the Mississippi and Ohio river valleys of the United States, is caused by infection with a fungus of the genus Histoplasma (H. capsulatum), and is marked by benign involvement of lymph nodes of the trachea and bronchi usually without symptoms or by severe progressive generalized involvement of the lymph nodes and macrophage-rich tissues (as of the liver and spleen) with fever, anemia, leukopenia and often with local lesions (as of the skin, mouth, or throat)
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