Medical Definition of grand mal
1 or grand mal epilepsy : severe epilepsy characterized by tonic-clonic seizures : tonic-clonic epilepsy
2 or grand mal seizure : a tonic-clonic seizure <She estimates having had about 25 grand mals and 100 smaller-scale seizures since.—Cicero A. Estrella, San Francisco Chronicle, 21 Dec. 2001>
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