genome

noun

ge·​nome ˈjē-ˌnōm How to pronounce genome (audio)
: one haploid set of chromosomes with the genes they contain
broadly : the genetic material of an organism compare proteome

Examples of genome in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Senior author Louise van der Weyden, a staff scientist at the Wellcome Sanger Institute in England, and a team of researchers sequenced the genomes of tumors from almost 500 domestic cats. K. R. Callaway, Scientific American, 19 Feb. 2026 The team identified a region in the banana genome that controls resistance to a strain of Fusarium wilt called Sub Tropical Race 4 (STR4), which affects bananas in subtropical regions. Laura Baisas, Popular Science, 19 Feb. 2026 When the company unveiled the dire wolves in April 2025, some argued that even though Colossal analyzed ancient dire wolf DNA, some from 72,000 years ago, the animals were really spawned from a gray wolf genome with 20 genetic changes over 14 genes. Mike Snider, USA Today, 17 Feb. 2026 These included different regions of the genome across strains specific to arabica and robusta coffee. Lily Peck, The Conversation, 17 Feb. 2026 See All Example Sentences for genome

Word History

Etymology

German Genom, from Gen gene + -om (as in Chromosom chromosome)

First Known Use

1926, in the meaning defined above

Time Traveler
The first known use of genome was in 1926

Browse Nearby Words

Cite this Entry

“Genome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genome. Accessed 25 Feb. 2026.

Medical Definition

genome

noun
ge·​nome ˈjē-ˌnōm How to pronounce genome (audio)
: one haploid set of chromosomes with the genes they contain
broadly : the genetic material of an organism
The idea behind sequencing an organism's genome—decoding, letter by letter, the message contained in every last one of its genes—is that it would tell us a lot about how the organism works. Lori Oliwenstein, Discover

More from Merriam-Webster on genome

Last Updated: - Updated example sentences
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!

More from Merriam-Webster