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fissure1: a natural cleft between body parts or in the substance of an organ: as a: any of several clefts separating the lobes of the liver b: any of various clefts between bones or parts of bones in the skull c: any of the deep clefts of the brain; especially : one of those located at points of elevation in the walls of the ventricles—compare sulcus d: anterior median fissure; also : posterior median septum2: a break or slit in tissue usually at the junction of skin and mucous membrane <fissure of the lip>3: a linear developmental imperfection in the enamel of a tooth
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