Medical Definition of erythroblastosis fetalis
: a hemolytic disease of the fetus and newborn that is characterized by an increase in circulating erythroblasts and by jaundice and that occurs when the system of an Rh-negative mother produces antibodies to an antigen in the blood of an Rh-positive fetus which cross the placenta and destroy fetal red blood cells—called also hemolytic disease of the newborn, Rh disease
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