Medical Definition of denature
: to deprive of natural qualities: asa: to make (alcohol) unfit for drinking (as by adding an obnoxious substance) without impairing usefulness for other purposesb: to modify the molecular structure of (as a protein or DNA) especially by heat, acid, alkali, or ultraviolet radiation so as to destroy or diminish some of the original properties and especially the specific biological activity
: to become denatured
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