Medical Definition of antinuclear
: being antibodies or autoantibodies that react with components and especially DNA of cell nuclei and that tend to occur frequently in connective tissue diseases (as systemic lupus erythematosus, rheumatoid arthritis, and Sjögrens syndrome)
Learn More about antinuclear
Dictionary: Definition of "antinuclear"
Seen and Heard
What made you want to look up antinuclear? Please tell us where you read or heard it (including the quote, if possible).