antinuclear

an·ti·nu·cle·ar

adj \-ˈn(y)ü-klē-ər\

Definition of ANTINUCLEAR

: being antibodies or autoantibodies that react with components and especially DNA of cell nuclei and that tend to occur frequently in connective tissue diseases (as systemic lupus erythematosus, rheumatoid arthritis, and Sjögrens syndrome)