Alport syndrome

Al·port syndrome

noun \ˈal-ˌpȯrt-\

Definition of ALPORT SYNDROME

: a usually X-linked inherited disorder that is typically more severe in males, is characterized especially by hematuria, hearing loss, abnormalities of the eye, and progressive renal failure, and is caused by defective or absent collagen normally present in basement membranes

Biographical Note for ALPORT SYNDROME

Alport, Arthur Cecil (1880–1959), British physician. Born in South Africa and trained in Edinburgh, Scotland, Alport served with the Royal Army Medical Corps in South West Africa and the Balkans during World War I. After the war he worked as a specialist in tropical medicine for the Ministry of Pensions in London. Beginning in 1922 he served as assistant director of a newly established medical unit at St. Mary's Hospital. In 1927 he reported on three generations of a family with combinations of progressive hereditary nephritis and deafness, noting that hematuria was the most common presenting symptom. In 1937 he went to Cairo to take the post of professor of medicine at King Faud I Hospital, but he later returned to his old hospital in London. The eponym Alport syndrome was coined in his honor in 1961.

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