Medical Definition of adrenoleukodystrophy
: a rare demyelinating disease of the central nervous system that is inherited as an X-linked recessive trait chiefly affecting males in childhood and that is characterized by progressive blindness, deafness, tonic spasms, and mental deterioration—abbreviation ALD; called also encephalitis periaxialis diffusa, Schilder's disease, Schilder's encephalitis
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