Dictionary

vicissitude

vicissitude

noun vi·cis·si·tude \və-ˈsi-sə-ˌtüd, vī-, -ˌtyüd\

Definition of VICISSITUDE

1
a :  the quality or state of being changeable :  mutability
b :  natural change or mutation visible in nature or in human affairs
2
a :  a favorable or unfavorable event or situation that occurs by chance :  a fluctuation of state or condition <the vicissitudes of daily life>
b :  a difficulty or hardship attendant on a way of life, a career, or a course of action and usually beyond one's control
c :  alternating change :  succession

Origin of VICISSITUDE

Middle French, from Latin vicissitudo, from vicissim in turn, from vicis change, alternation — more at week
First Known Use: circa 1576

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