noun \vak-ˈsi-nē-ə\

Definition of VACCINIA

:  a poxvirus (species Vaccinia virus of the genus Orthopoxvirus) that differs from but is closely related to the viruses causing smallpox and cowpox and that includes a strain of uncertain natural origin used in making vaccines against smallpox —called also vaccinia virus
:  a reaction to smallpox vaccine prepared from live vaccinia virus that may involve a rash, fever, headache, and body pain
vac·cin·i·al \-nē-əl\ adjective

Origin of VACCINIA

New Latin, from vaccinus
First Known Use: 1803


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