plural STIs
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Examples of STI in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
In the show, The Beauty is an STI that transforms a person into someone physically perfect, but with deadly consequences. Barry Levitt, Time, 22 Jan. 2026 Experts told Flow Space that these approvals are major shots across the bow in the fight against increasing STI rates. Helen Carefoot, Flow Space, 30 Dec. 2025 The Mecklenburg County Public Health Department has also provided STI testing and education to 54 individuals — some unhoused, others not. Briah Lumpkins, Charlotte Observer, 5 Dec. 2025 The latter includes the 2014 Subaru Impreza WRX STI, one of the last cars driven by Paul Walker in the Fast & Furious movies. Lydia Mansel, Travel + Leisure, 30 Nov. 2025 Only one of the five public health nurses needed to fully staff the STI clinic remains with the health department, a spokesperson said. Sarah Volpenhein, jsonline.com, 13 Nov. 2025 The biggest announcement at this year’s Tokyo Motor Show—now called the Japan Mobility Show—might be the new Corolla concept, the new Subaru WRX STI hatchback, or several new Lexus LS variants. Erik Shilling, Robb Report, 12 Nov. 2025 Spoken by Milan to Allura while waiting for STI tests from a doctor supposedly not accepting new patients before 2040. David Rooney, HollywoodReporter, 10 Nov. 2025 In men, the STI can inflame the epididymis, also sometimes causing infertility. Daryl Austin, USA Today, 10 Oct. 2025

Word History

Etymology

sexually transmitted infection

First Known Use

1983, in the meaning defined above

Time Traveler
The first known use of STI was in 1983

Browse Nearby Words

Cite this Entry

“STI.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/STI. Accessed 7 Feb. 2026.

Medical Definition

STI

abbreviation or noun
: any of various diseases or infections (such as gonorrhea, genital herpes, chlamydia, hepatitis B, or HIV) that are typically transmitted by direct sexual contact but may sometimes be spread by nonsexual means (such as childbirth or sharing needles)

called also STD

Last Updated: - Updated example sentences
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