City (pop., 2000: 107,789), northern Indiana, U.S. It is situated on the St. Joseph River. A fur-trading post was established at the site in 1820. The city's highly industrialized economy has roots in the pioneering companies founded there in the 19th century, including Studebaker Brothers Manufacturing Co. (later an auto plant) and Singer Co., a sewing machine manufacturer. The city serves as the trade and financial focus of southern Michigan as well as northern Indiana, a region known as Michiana. Nearby is the University of Notre Dame.