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Definition of NIGHTSHADE
: any of a genus (Solanum of the family Solanaceae, the nightshade family) of herbs, shrubs, and trees having alternate leaves, cymose flowers, and fruits that are berries and including some poisonous weeds, various ornamentals, and important crop plants (as the potato and eggplant)
: any plant of the genus Solanum (family Solanaceae, the nightshade family) which includes some poisonous weeds, various ornamental garden plants, and important crop plants (as the potato and eggplant)