Origin of neurofibromatosis
New Latin, from neurofibromat-, neurofibroma
First Known Use: 1896
Medical Definition of neurofibromatosis
plural neurofibromatoses \-ˌsēz\play
1 also neurofibromatosis type 1 or neurofibromatosis 1 : an inherited developmental disorder characterized especially by brown spots on the skin that are typically present at birth, neurofibromas of peripheral nerves, and deformities of subcutaneous tissues and bone—abbreviation NF, NF-1; called also Recklinghausen's disease, von Recklinghausen's disease
2 also neurofibromatosis type 2 or neurofibromatosis 2 : an inherited disorder characterized by bilateral acoustic neuromas developing in childhood or early adulthood that are typically accompanied by other nonmalignant tumors of the central nervous system—abbreviation NF, NF-2 ◆Both types of neurofibromatosis are inherited as an autosomal dominant trait requiring that one parent pass on a copy of the defective gene on a chromosome other than a sex chromosome. Type 1 is much more common than type 2.
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