City (pop., 2006 est.: 2,223,148), central Honshu, Japan. Located east of Kyoto, at the head of Ise Bay, it is one of Japan's leading industrial cities. Manufactures include textiles, watches, bicycles, sewing machines, machine tools, chemicals, and ceramics. The city dates from 1610, when a large castle was erected by the Owari branch of the Tokugawa shogunate; the castle was destroyed during World War II and rebuilt in 1959. The city's educational and cultural institutions include Nagoya University and the Tokugawa Art Museum. The Atsuta Shrine in Nagoya and nearby Ise Shrine are the oldest and most highly esteemed Shinto shrines in Japan.