melanoma

noun

mel·​a·​no·​ma ˌme-lə-ˈnō-mə 

plural melanomas also melanomata ˌme-lə-ˈnō-mə-tə 

1

: a tumor containing dark pigment

2

: a highly malignant tumor that starts in melanocytes of normal skin or moles and metastasizes rapidly and widely

Examples of melanoma in a Sentence

Recent Examples on the Web

When tested on human T cells, which had been developed to recognize a range of tumor antigens, zeaxanthin bolstered the immune cells' power in killing off melanoma, multiple myeloma and glioblastoma cells. —New Atlas, 3 Sep. 2025

The Real Housewives of Beverly Hills alum, 44, has stage 4 melanoma that has metastasized to her brain and lungs. —Vanessa Etienne, People.com, 26 Aug. 2025

As a stage 3 melanoma survivor, Koutsoumpas understands how deeply caregiving can touch our lives. —Wes Kilgore, Forbes.com, 25 Aug. 2025

According to an Air Force study, these individuals experienced higher rates of melanoma, thyroid cancer and prostate cancer. —Center Square, The Washington Examiner, 23 Aug. 2025

Word History

Etymology

melan- (in melanosis, melanotic) + -oma

First Known Use

1838, in the meaning defined at sense 1

Phrases Containing melanoma

• malignant melanoma

Rhymes for melanoma

• ambystoma
• atheroma
• carcinoma
• coloboma
• granuloma
• haematoma
• hamartoma
• hemangioma
• hematoma
• hepatoma
• hybridoma
• myeloma

Kids Definition

melanoma

noun

mel·​a·​no·​ma ˌmel-ə-ˈnō-mə 

plural melanomas also melanomata -mət-ə 

: a usually malignant tumor containing dark pigment

Medical Definition

melanoma

noun

mel·​a·​no·​ma ˌmel-ə-ˈnō-mə 

plural melanomas also melanomata -mət-ə 

1

: a benign or malignant skin tumor containing dark pigment

2

: a tumor of high malignancy that starts in melanocytes of normal skin or moles and metastasizes rapidly and widely

called also malignant melanoma, melanocarcinoma, melanoepithelioma, melanosarcoma