City (pop., 2000: 25,478), southwestern Florida, U.S. The southernmost city of the continental U.S., it lies on an island about 4 mi (6.5 km) long and 1.5 mi (2.4 km) wide in the western Florida Keys. The name is an English corruption of Cayo Hueso (Bone Islet), as it was called by Spanish explorers who found human bones there. In 1822 a U.S. naval depot was set up on Key West as a base of operations against pirates. Now a winter resort, Key West is also a tourist destination. Many writers and artists have lived there, and the homes of Ernest Hemingway and John James Audubon have been preserved.