goitre


goi·tre

Definition of GOITRE

chiefly British variant of goiter

goitre

   (Concise Encyclopedia)

Enlargement of the thyroid gland, causing a prominent swelling in the front of the neck. The thyroid normally weighs 0.5 to 0.9 oz (15 to 25 g); however, goitrous thyroid glands can grow to more than 2 lbs (1,000 g). A large goitre may interfere with breathing and swallowing and cause a choking feeling. Endemic goitre, the most common, is due to iodine deficiency, which causes a reduction in thyroid hormone synthesis (hypothyroidism). As a result, there is a compensatory increase in secretion of the anterior pituitary hormone thyrotropin. Thyrotropin not only stimulates thyroid hormone production but also causes an increase in size and number of cells in the thyroid. Advanced cases are treated with thyroid hormone or with surgical removal of the thyroid if it obstructs breathing. There are numerous other causes of goitre, including defects in thyroid hormone synthesis and inflammation of the thyroid. An enlarged thyroid may have normally functioning tissue or may produce too much hormone (hyperthyroidism). See also Graves disease.

Browse

Next Word in the Dictionary: goitrogen
Previous Word in the Dictionary: goiter stick
All Words Near: goitre

Seen & Heard

What made you want to look up goitre? Please tell us where you read or heard it (including the quote, if possible).

Get Our Free Apps
Voice Search, Favorites,
Word of the Day, and More
Join Us on FB & Twitter
Get the Word of the Day and More