: one haploid set of chromosomes with the genes they contain
broadly
: the genetic material of an organism compare proteome
Examples of genome in a Sentence
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Researchers analyzing the remains recovered a genome of Treponema pallidum, the bacterium responsible for syphilis and three other treponemal diseases.
—
Andrea Margolis, FOXNews.com, 29 Jan. 2026
And in 2023 DeepMind released AlphaMissense, another AI tool that predicts how mutations in the regions of the genome that do generate proteins affect gene function.
—Tanya Lewis, Scientific American, 28 Jan. 2026
But the virus does accumulate some changes in its genome, and the further apart two cases are in time, the more genetically distinct their genetic material should be.
—Katherine J. Wu, The Atlantic, 27 Jan. 2026
However, the Colombian genome predates these by several thousand years, indicating that the pathogen was circulating earlier than scientists had previously understood.
—Maria Mocerino, Interesting Engineering, 24 Jan. 2026
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Andrea Margolis, FOXNews.com, 29 Jan. 2026
And in 2023 DeepMind released AlphaMissense, another AI tool that predicts how mutations in the regions of the genome that do generate proteins affect gene function.
—Tanya Lewis, Scientific American, 28 Jan. 2026
But the virus does accumulate some changes in its genome, and the further apart two cases are in time, the more genetically distinct their genetic material should be.
—Katherine J. Wu, The Atlantic, 27 Jan. 2026
However, the Colombian genome predates these by several thousand years, indicating that the pathogen was circulating earlier than scientists had previously understood.
—Maria Mocerino, Interesting Engineering, 24 Jan. 2026
See All Example Sentences for genome
Cite this Entry
“Genome.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/genome. Accessed 4 Feb. 2026.
Copy CitationMedical Definition
genome
noun
ge·nome
ˈjē-ˌnōm 
: one haploid set of chromosomes with the genes they contain
broadly
: the genetic material of an organism
The idea behind sequencing an organism's genome—decoding, letter by letter, the message contained in every last one of its genes—is that it would tell us a lot about how the organism works. —Lori Oliwenstein, Discover
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