fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Drug dealers mix fentanyl, because of its potency and low cost, with other drugs including heroin, methamphetamine and cocaine, which increases the likelihood of a fatal dose, according to the DEA. Rosalio Ahumada, Sacbee.com, 16 June 2026 Naval Criminal Investigative Service agents and base personnel tracked two suspects while ordering residents to shelter in place, then discovered 51 kilograms of cocaine and fentanyl inside the deserted vehicle. Jasmine Mendez, Los Angeles Times, 14 June 2026 Investigators later discovered approximately 51 kilograms — more than 112 pounds — of cocaine and fentanyl inside the suspects' vehicle, according to NCIS. Michael Sinkewicz, FOXNews.com, 14 June 2026 About 51 kilograms, or approximately 112 pounds, of cocaine and fentanyl were seized. Austin Turner, CBS News, 13 June 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

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Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 18 Jun. 2026.

Medical Definition

fentanyl

noun
fen·​ta·​nyl ˈfent-ᵊn-ˌil How to pronounce fentanyl (audio)
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

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