fentanyl

noun

fen·​ta·​nyl ˈfen-tə-ˌnil How to pronounce fentanyl (audio)
nonstandard -ˌnȯl
: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally (as by intravenous or epidural injection)

Examples of fentanyl in a Sentence

Recent Examples on the Web
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Prosecutors said Freire supplied fentanyl disguised as cocaine to two female students at the college. — Lisa Rozner, CBS News, 28 Oct. 2026 Court records show that members of the FBI’s Safe Streets Gang Task Force uncovered evidence that Burruss was reportedly selling fentanyl in and around New Haven. — Staff Report, Hartford Courant, 28 Oct. 2026 The Greenville County Coroner’s Office in September determined Panettiere died from the toxic effects of fentanyl, 4-ANPP, Alprazolam, Methocarbamol, and Quetiapine, and the manner of death ruled accidental. — Denise Petski, Deadline, 28 Oct. 2026 The actress died from a toxic mix of the opioid fentanyl and other drugs, authorities said in September. — Cindy Von Quednow, CNN Money, 28 Oct. 2026 See All Example Sentences for fentanyl

Word History

Etymology

probably alteration of phenethyl, a monovalent radical derived from ethylbenzine, from phen- + ethyl

First Known Use

1964, in the meaning defined above

Time Traveler
The first known use of fentanyl was in 1964

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Cite this Entry

“Fentanyl.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/fentanyl. Accessed 1 Nov. 2026.

Medical Definition

: a synthetic opioid narcotic analgesic C22H28N2O with pharmacological action similar to morphine that is administered transdermally as a skin patch and in the form of its citrate C22H28N2O·C6H8O7 is administered orally or parenterally

Note: Fentanyl is marketed under the trademark Actiq.

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