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After feeling the lump, Johnson's doctor determined that the mass could be cancerous but was most likely epididymitis.—Chanel Vargas, InStyle, 11 June 2026 When this tube becomes inflamed it is called epididymitis.—Patty Weasler, Rn, Bsn, Verywell Health, 9 Jan. 2025 Another thing to watch out for is epididymitis, which happens when the epididymis, the coiled tube that brings sperm to the outside world, becomes inflamed—in this case due to a chlamydia infection, according to the Mayo Clinic.—Rozalynn S. Frazier, SELF, 20 Jan. 2022