Definition of antimetabolite
: a substance that replaces or inhibits an organism's utilization of a metabolite
First Known Use of antimetabolite
Medical Definition of antimetabolite
: a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite <Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.—Jane E. Brody, The New York Times, 15 May 1985> <antimetabolite therapy>
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