Definition of antimetabolite
: a substance that replaces or inhibits an organism's utilization of a metabolite
First Known Use of antimetabolite
Medical Definition of antimetabolite
: a substance (as a sulfa drug) that replaces or inhibits the utilization of a metabolite <Antimetabolites, such as methotrexate masquerade as essential nutrients, which the cell uses instead of real nutrients and thus dies.—Jane E. Brody, The New York Times, 15 May 1985> <antimetabolite therapy>
antimetabolic\-ˌmet-ə-ˈbäl-ik\ play adjective <In addition to its antimetabolic effects, methotrexate has immunological effects …—Robert S. Stern, The Lancet, 2 Aug. 1997>
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