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antagonist1: one that contends with or opposes another : adversary, opponent2: an agent of physiological antagonism: as a: a muscle that contracts with and limits the action of an agonist with which it is paired —called also antagonistic muscle b: a chemical that acts within the body to reduce the physiological activity of another chemical substance (as an opiate)
; especially : one that opposes the action on the nervous system of a drug or a substance occurring naturally in the body by combining with and blocking its nervous receptor
— compare agonist 2b
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