: the effects (as nosebleed, nausea, or headache) of oxygen deficiency in the blood and tissues developed at high altitudes with reduced atmospheric pressure
Acute reaction to a change from low altitudes to altitudes above 8,000 ft (2,400 m). Most people gradually adapt, but some have a severe reaction that can be fatal unless they return to low altitude. Normal adaptations to the reduced oxygen at high altitude (e.g., breathlessness, racing heartbeat) are exaggerated; other manifestations include headache, gastrointestinal upsets, and weakness. Pulmonary edema is quickly reversed with oxygen and evacuation to a lower area.