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Huntington's disease

noun Hun·ting·ton's disease \ˈhən-tiŋ-tənz-\

Definition of Huntington's disease

  1. :  a chorea usually beginning in middle age that is inherited as an autosomal dominant trait and progresses to dementia —called also Huntington's chorea

Origin of huntington's disease

George Huntington †1916 American physician

First Known Use: 1892

Medical Dictionary

Huntington's disease

noun Hun·ting·ton's disease \ˌhənt-iŋ-tənz-\

Medical Definition of Huntington's disease

  1. :  a hereditary brain disorder that is a progressive, neurodegenerative condition marked especially by impairments in thinking and reasoning, disturbances of emotion and behavior, and the involuntary spasmodic movements of chorea and is associated with the loss or atrophy of nerve cells in the basal ganglia especially of the caudate nucleus and putamen Huntington's disease is inherited as an autosomal dominant trait requiring only one parent to pass on a copy of the defective gene on a chromosome other than a sex chromosome. While it may have an onset at any age, people most often become symptomatic between 30 to 50 years of age. The most common symptoms of Huntington's disease include depression, irritability, mood swings, deficits in memory and concentration, dementia, difficulty in swallowing, jerky movements, and loss of coordination.

Biographical Note for huntington's disease

Huntington, George (1850–1916), American neurologist. Huntington was a family doctor who published only one medical document, his description of chronic hereditary chorea. His description of 1872, although not the first, is noted for its detailed recounting of the symptoms, especially the regression that eventually results in dementia. The earliest known description of this type of chorea is by Charles O. Waters (1816–1892), published in 1842 in a work by the American physiologist Robley Dunglison (1798–1869).

Variants of huntington's disease

also Huntington disease or Huntington's chorea or Huntington's

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