plural E. coli
: an enterobacterium (Escherichia coli) that is used in public health as an indicator of fecal pollution (as of water or food) and in medicine and genetics as a research organism and that occurs in various strains that may live as harmless inhabitants of the human lower intestine or may produce a toxin causing intestinal illness see enterobacterium illustration

Examples of E. coli in a Sentence

Recent Examples on the Web
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After storms, especially near discharging storm drains, creeks and rivers, the water can be contaminated with E. coli, trash, chemicals and other public health hazards. Stacy Perman, Los Angeles Times, 4 Jan. 2026 Packages of ground beef that were distributed in six states are being recalled for concerns of E. coli contamination. James Powel, USA Today, 30 Dec. 2025 According to an announcement from the U.S. Department of Agriculture’s Food Safety and Inspection Service (FSIS), published on Saturday, Dec. 27, the contaminated beef products tested positive for the presence of E. coli O26 in a routine FSIS testing and sampling. Moná Thomas, PEOPLE, 29 Dec. 2025 An Idaho food distributor is recalling nearly 3,000 pounds of raw ground beef because of concerns about E. coli contamination. Sam Tabachnik, Denver Post, 29 Dec. 2025 See All Example Sentences for E. coli

Word History

First Known Use

1925, in the meaning defined above

Time Traveler
The first known use of E. coli was in 1925

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Cite this Entry

“E. coli.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/E.%20coli. Accessed 21 Jan. 2026.

Kids Definition

E. coli

noun
plural E. coli
: a bacterium in the shape of a short rod that may cause intestinal illness
Etymology

short for Escherichia coli, the taxonomic name in biology

Medical Definition

E. coli

noun
ˌē-ˈkō-ˌlī
plural E. coli also E. colis
: a straight rod-shaped gram-negative bacterium (Escherichia coli of the family Enterobacteriaceae) that is used in public health as an indicator of fecal pollution (as of water or food) and in medicine and genetics as a research organism and that occurs in various strains that may live as harmless inhabitants of the human lower intestine or may produce a toxin causing intestinal illness marked especially by diarrhea
one million acid-resistant E. coli per gram of fecesJohn Schwartz
this E. coli can survive … longer than all the other E. colisEd Geldreich
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