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Any of a class of proteins that are secreted by cells and are inactive precursors of enzymes. Transformation into active enzymes occurs as one or more peptide bonds in the zymogen are cleaved. Examples include trypsinogen and chymotrypsinogen, secreted by the pancreas and converted by proteolysis in the small intestine into the active enzymes trypsin and chymotrypsin; and numerous coagulation factors.
Variants of ZYMOGEN
zymogen or proenzyme
This entry comes from Encyclopædia Britannica Concise. For the full entry on zymogen, visit Britannica.com.