Paget disease of bone


Paget disease of bone

Chronic bone disease of middle age. Named for James Paget, it is characterized by excessive bone destruction alternating with disordered bone construction (with dense, brittle bones and deformity that can compress internal structures). The long bones, vertebrae, pelvis, and skull are most often affected, more often in men. The risk of cancer, usually osteosarcoma, is high. Increased blood supply to the area of bone destruction may lead to heart or circulatory problems. Calcitonin (which regulates bone growth) and bisphosphonates (which block excessive bone breakdown) are drugs of treatment.

Variants of PAGET DISEASE OF BONE

Paget disease of bone or osteitis deformans

This entry comes from Encyclopædia Britannica Concise.
For the full entry on Paget disease of bone, visit Britannica.com.

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