Inflammation of the heart lining (endocardium), in association with a noninfectious disease (e.g., systemic lupus erythematosus) or caused by infection, usually at the heart valves. Severe bacterial infection causes an acute form with fever, sweating, chills, joint pain and swelling, and embolisms. Subacute endocarditis usually comes from bacteria that do not ordinarily cause disease. Bacterial endocarditis is usually treated with long-term antibiotics. In nonbacterial thrombotic endocarditis, blood clots form along heart valve edges.
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